Treatment Information

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Brain – Glioblastoma Multiforme treatment details. Chemotherapy, Radiation.

University of Rochester School of Medicine and Dentistry, Rochester, New York, United States.

Survival: monthsCountry:United States
Toxiciy Grade:5City/State/Province:Rochester, New York
Treatments:Chemotherapy, RadiationHospital:University of Rochester School of Medicine and Dentistry
Drugs:Journal:Link
Date:Apr 2003

Description:

Patients: This Phase I study involved a total of 29 patients with recurrent malignant gliomas. Nineteen patients had glioblastoma multiforme, 3 had gliosarcoma, 5 had anaplastic astrocytoma, and two had oligoastrocytoma.

Treatment: The treatment consisted of two chemotherapy drugs, temozolomide (temodar) and oral etoposide (VP-16, vepesid).

Toxicity: Two patients died from pneumonia. Other toxicities included fever, neutropenia, infection, nausea, vomiting, constipation, fatigue, pain, weight loss, headache, and seizure.

Results: Overall survival was not discussed.

Support: The study was supported in part by a grant from Schering-Plough, the manufacturer of temozolomide.

Correspondence: David N. Korones, MD






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