Treatment Information

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Brain – Glioblastoma Multiforme treatment details. Chemotherapy, Biologic therapy.

Mayo Clinic, Rochester, MN, United States.

Survival: monthsCountry:United States
Toxiciy Grade:4City/State/Province:Rochester, MN
Treatments:Chemotherapy, Biologic therapyHospital:Mayo Clinic
Drugs:Journal:Link
Date:Nov 2011

Description:

Patients:
This phase II study involved 37 recurrent glioblastoma (GBM) patients with a median age of 51.5 years; 73% were male.

Treatment:
Patients were treated with the chemotherapy drug vorinostat and the biologic therapy drug bortezomib, which inhibits the proteasome complex in cells and causes cell death.

Toxicities:
The most severe adverse reactions were grade 4 thrombocytopenia and neutropenia. Grade 3 fatigue was also reported.

Results:
The median overall survival was 3.2 months.

Correspondence: Dr. Evanthia Galanis; email: [email protected]



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