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Liver Cancer treatment details. Biologic therapy.

Mayo Clinic Florida, Jacksonville, FL, United States.

Survival: monthsCountry:United States
Toxiciy Grade:4City/State/Province:Jacksonville, FL
Treatments:Biologic therapyHospital:Mayo Clinic Florida
Drugs:Journal:Link
Date:Sep 2010

Description:

Patients:
This phase II study involved 35 patients with surgically unresectable or metastatic hepatocellular carcinoma. The median age was 61 years and 80% of the patients were male.

Treatment:
Patients were treated with a biologic therapy bortezomib, which is a proteosome inhibitor. This drug blocks protein production in cancer cells, which can lead to cell death.

Toxicities:
The maximum toxicity level reported in this study was grade 4 and included thrombosis (2 cases), hepatic failure (1) and hypoglycemia (1).

Results:
The median overall survival in this study was 6.0 months.

Correspondence: Dr. George P. Kim; email:[email protected]



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