Treatment Information

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Mesothelioma treatment details. Chemotherapy.

The Netherlands Cancer Institute, Amsterdam, Netherlands.

Survival: monthsCountry:Netherlands
Toxiciy Grade:3City/State/Province:Amsterdam
Treatments:ChemotherapyHospital:The Netherlands Cancer Institute
Drugs:Journal:Link
Date:Feb 2003

Description:

Patients: This Phase II study involved 24 patients with malignant pleural mesothelioma; 19 men and 5 women. The median age was 63 years.

Treatment: The treatment consisted of the drug raltitrexed (tomudex). This agent inhibits the enzyme thymidylate synthase which is involved in the synthesis of DNA.

Toxicity: Grade 3-4 toxicities included anorexia, shortness of breath/dyspnea, hematologic, febrile neutropenia, nausea/vomiting, neurological toxicity, chest pain, pleuritic pain, and cough.

Results: The overall median survival was 7 months.

Support: AstraZeneca provided the drug (Tomudex) free of charge.

Correspondence: P. Baas, MD




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