Treatment Information

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Brain – Glioblastoma Multiforme treatment details. Radiation.

University of California San Francisco, San Francisco, California, United States.

Survival: monthsCountry:United States
Toxiciy Grade:City/State/Province:San Francisco, California
Treatments:RadiationHospital:University of California San Francisco
Drugs:Journal:Link
Date:Jan 2001

Description:

Patients: This study included 231 patients with newly diagnosed glioblastoma multiforme. (Six patients were later determined to have a gliosarcoma.) The patients were divided into four treatment groups.

1. Group A – Accelerated hyperfractionated irradiation with 44 fractions of 1.6 Gy to a total dose of 70.4 Gy. Administered to 57 patients.
2. Group B – Accelerated hyperfractionated irradiation with 44 fractions of 1.6 Gy to a total dose of 70.4 Gy plus DFMO. Administered to 57 patients.
3. Group C – Standard fractionated irradiation with 33 fractions of 1.8 Gy to a total of 59.4 Gy. Administered to 58 patients.
4. Group D - Standard fractionated irradiation with 33 fractions of 1.8 Gy to a total of 59.4 Gy plus DFMO. Administered to 59 patients.

Treatment: Group C – Standard fractionated irradiation with 33 fractions of 1.8 Gy to a total of 59.4 Gy.

Toxicity: In Group C, there were no grade 3 or 4 toxicities noted for this group. Lesser toxicities were not detailed.

Results: Overall survival for group C was 37 weeks (i.e. 8.5 months).

Correspondence: M. Prados, MD




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