Treatment Information

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Liver Cancer treatment details. Biologic therapy.

Massachusetts General Hospital Cancer Center, Boston, MA, United States.

Survival: monthsCountry:United States
Toxiciy Grade:5City/State/Province:Boston, MA
Treatments:Biologic therapyHospital:Massachusetts General Hospital Cancer Center
Drugs:Journal:Link
Date:Jul 2015

Description:

Patients:
This phase 3 study involved 283 advanced hepatocellular carcinoma patients who were previously treated with sorafenib. The median patient age was 64 years and 83% were male.

Treatment:
Patients received biologic therapy with ramucirumab, a monoclonal antibody specific to the VEGFR-2 that inhibits cancer cell growth.

Toxicities:
Treatment-related deaths due to respiratory distress, kidney failure, and bleeding/hemorrhage were reported. Grade 4 decreased appetite and grade 3 high blood pressure were also reported.

Results:
The median overall survival was 9.2 months.

Support:
This study was supported by Eli Lilly and Co.

Correspondence: Dr. Andrew X Zhu; email: [email protected]



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