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Liver Cancer treatment details. Radiation, Biologic therapy.

National Institute of Cancer Research, Tainan, Taiwan Region.

Survival: monthsCountry:Taiwan Region
Toxiciy Grade:4City/State/Province:Tainan
Treatments:Radiation, Biologic therapyHospital:National Institute of Cancer Research
Drugs:Journal:Link
Date:Jan 2011

Description:

Patients:
In this study, patients with hepatocellular carcinoma were divided into 2 treatment groups. Group A included 18 patients, 83.3% were male and 72.2% were under the age of 70. In group B, there were 24 patients, 83.3% of whom were male, and 79.2% were under the age of 70.

Treatment:
Group A was treated with radiation alone. Group B was treated with radiation and the biologic agent thalidomide, which inhibits the formation of blood vessels in the tumor, therefore blocking tumor growth.

Toxicities:
The maximum level of toxicity for both groups was grade 4. Grade 3-4 adverse events in group A included infection (reported in 16.7% of patients) and liver dysfunction (38.9%). Grade 3-4 events reported in group B included skin rash (20.8% of patients) and liver dysfunction (37.5%).

Results:
The median progression-free survival for group A was 6.0 months and the median overall survival was 8.5 months. For group B, the median, progression-free survival was 4.9 months and the median overall survival was 7.9 months.

Correspondence: Dr. Hui-Ju Ch’ang; email: [email protected]

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