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Actos Alert


  • On April 8, 2014, a jury ordered the drug companies that make and market Actos to pay $9 Billion to Terrence Allen who was diagnosed with bladder cancer after taking Actos.
  • According to the FDA, all Actos products may be associated with an increased risk of bladder cancer.
  • Actos products are manufactured by a company called Takeda Pharmaceuticals which is a large Japanese pharmaceutical company.
  • Over 5,000 Actos related cases have already been filed by people diagnosed with bladder cancer.

To find out if you have a claim, please fill-out this form and you will be contacted by a law firm that specializes in representing bladder cancer victims who took Actos. Filling out the form does not commit you to filing a claim. After talking to the law firm, you can decide if you want to pursue a claim or not.

Only fill-out this form if you took Actos or Actoplus Met or Actoplus Met XR or Duetact and were later diagnosed with bladder cancer.

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Jury Awards $6.5 Million in First Actos-Bladder Cancer Case


Hon. Kenneth Freeman
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On April 26, 2013, a court awarded $6.5 million in the first Actos bladder cancer case to go to trial (Jack Cooper v. Takeda Pharmaceuticals America Inc., CGC-12-518535, Calif. Super., Los Angeles Co.).

A jury in the Los Angeles County Superior Court awarded $5 million in compensatory damages to plaintiff Jack Cooper and $1.5 million to his wife.

Seventy-nine year old, Jack Cooper, took Actos for more than five years to treat his diabetes. In 2011, he was diagnosed with bladder cancer. Mr. Cooper sued Takeda, the Japanese pharmaceutical company that makes Actos. Mr. Cooper alleged that as a result of taking Actos, he developed bladder cancer. Cooper says his cancer spread to his appendix, pelvic lymph nodes, and lungs. Dr. Norm D. Smith, an assistant professor of urology and surgery at the University of Chicago, testified that Actos was the most likely cause of the plaintiff’s advanced cancer.

After a two month trial and 5 days of deliberation, the jury returned a verdict in favor of Mr. Cooper. The judge (Hon. Kenneth Freeman) subsequently sided with Takeda and vacated the award. However, thousands of other claimants have already filed Actos bladder cancer lawsuits. They believe that Actos caused their bladder cancer.

Scientists Find an Actos (pioglitazone) Connection

Does Actos Cause Bladder Cancer? While the research is not unequivocal, many studies suggest the answer is “yes.” These quotes come from studies performed by medical doctors and scientists throughout the world. They use the term “pioglitazone” which is the generic word for the drug Actos.

Dr. Romero



“Prospective studies suggested an association between pioglitazone (Actos) use and the development of bladder cancer.”

Romero V, et. al., Pathology of bladder cancer among diabetic patients undergoing radical cystectomy with a history of pioglitazone (Actos) use. BMC Urol. 2014 Jan 25;14(1):10.

“A modest but clinically significant increased risk of bladder cancer with pioglitazone was found that appears related to cumulative dose and duration of exposure.”

Loke, YK, et al., Thiazolidinediones and associated risk of Bladder Cancer: a Systematic Review and Meta-analysis. Br J Clin Pharmacol. 2013 Dec 10. doi: 10.1111/bcp.12306. [Epub ahead of print]

Dr. Loke

“With some limitations, our results suggest an increased risk of bladder cancer in diabetic patients using pioglitazone, especially for men with long-term and high-dose exposure.”

He S, et al., Pioglitazone prescription increases risk of bladder cancer in patients with type 2 diabetes: an updated meta-analysis. Tumour Biol. 2013 Oct 4.


“Pioglitazone treatment appears to be associated with a significantly increased risk of bladder cancer in patients with diabetes.”

Zhu Z, et al., Increased risk of bladder cancer with pioglitazone therapy in patients with diabetes: a meta-analysis. Diabetes Res Clin Pract. 2012 Oct;98(1):159-63. doi: 10.1016/j.diabres.2012.05.006. Epub 2012 Jun 16.

Dr. Pollack

"The use of pioglitazone is associated with an increased risk of incident bladder cancer among people with type 2 diabetes.”

Pollack, M, et al., The use of pioglitazone and the risk of bladder cancer in people with type 2 diabetes: nested case-control study. BMJ. 2012 May 30;344:e3645. doi: 10.1136/bmj.e3645.

“In this cohort of diabetic patients from France, pioglitazone exposure was significantly associated with increased risk of bladder cancer.”

Neumann A, et al., Pioglitazone and risk of bladder cancer among diabetic patients in France: a population-based cohort study. Diabetologia. 2012 Jul;55(7):1953-62. doi: 10.1007/s00125-012-2538-9. Epub 2012 Mar 31.

Actos is Pulled from Market and Lawsuits Begin

As a result of these concerns, Actos has been pulled from the market in Germany, France and India. There is no ban in the USA although the FDA is actively reviewing the situation. Bladder cancer patients, thousands of them, are suing Takeda, the maker of Actos. They allege that the drug caused their bladder cancer and that Takeda knew this was a risk.

Judge Rules that the Maker of Actos May Have Destroyed Evidence

On January 27, 2014, the federal judge, Hon. Rebecca F. Doherty, ruled that Takeda breached its duty to preserve documents related to the lawsuits. The judge found that the drug company acted in “bad faith” in failing to preserve evidence that they were required to keep.

Hon. Rebecca F. Doherty
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One of the many pieces of evidence that Takeda was apparently unable to produce were communications between another company (Upjohn) and Takeda. Lawyers who represented the bladder cancer victims were able to produce some of these records from other sources. These communications allegedly indicate that Upjohn had concerns regarding the safety of Actos and that Takeda asked Upjohn to play down their safety concerns.

Don’t Wait to File a Claim

Cases are going on right now so now is the time to file a claim. Don't wait until it is too late. If Takeda is found responsible, settlements may be available to bladder cancer victims who already have filed their case. Click here to fill out the form and you will be contacted by a law firm that represents people who were diagnosed with bladder cancer after taking Actos.