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Bladder Cancer treatment details. Chemotherapy. Surgery. Sapporo Medical University School of Medicine, Sapporo, Japan



Survival: 102.0 months
   
Toxicity Grade: 4
   
Treatments: Chemotherapy
Surgery
   
Drugs: Methotrexate
Country: Japan
   
City/State/Province: Sapporo
   
Hospital: Sapporo Medical University School of Medicine
   
Journal: Link
   
Date: 6/2014

Description:
Patients:
This phase 3 study involved muscle-invasive bladder cancer patients who were divided into two separate treatment groups. Group A consisted of 66 patients with a median age of 63 years; 60 were male. Group B had 64 patients with a median age of 63 years; 57 were male.

Treatment:
Patients in group A received surgery (radical cystectomy).

Patients in group B received chemotherapy with methotrexate, doxorubicin, vinblastine and cisplatin, and surgery (radical cystectomy).

Toxicities:
The most severe toxicities in group A were of grade 4 and included grade 3-4 infection and thrombosis (blood clot).

The most severe toxicities in group B were grade 4 neutropenia and anemia. Grade 3 loss of appetite and nausea was also reported.

Results:
The median overall survival for groups A and B were 82 and 102 months, respectively.

Correspondence: Dr. Hiroshi Kitamura; email: hkitamu@sapmed.ac.jp

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