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Non-Hodgkin's Lymphoma treatment details. Chemotherapy. Radiation. Memorial Sloan-Kettering Cancer Center, New York, NY, United States



Survival: 79.2 months
   
Toxicity Grade: 5
   
Treatments: Chemotherapy
Radiation
   
Drugs: Methotrexate
Country: United States
   
City/State/Province: New York, NY
   
Hospital: Memorial Sloan-Kettering Cancer Center
   
Journal: Link
   
Date: 11/2013

Description:
Patients:
This phase 2 study involved 52 newly diagnosed primary central nervous system lymphoma patients. The median patient age was 60 years and 30 were male.

Treatment:
Patients were treated with a chemotherapy regimen of rituximab, methotrexate, procarbazine, vincristine, and cytarabine, and with radiation therapy.

Toxicities:
There were three treatment-related deaths due to neutropenia with fever. Grade 4 gastrointestinal perforation and grade 3 kidney toxicity were also reported.

Results:
The median overall survival was 79.2 months.

Support:
This study was partially supported by Genentech.

Correspondence: Dr. Antonio Omuro; email: omuroa@mskcc.org

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